US Surgeons Successfully Perform World’s First Human Eye Transplant

Surgeons have performed the world’s first transplant of an entire human eye, an extraordinary addition to a face transplant – although it’s far too soon to know if the man will ever see through his new left eye.

An accident with high-voltage power lines had destroyed most of Aaron James’s face and one eye. His right eye still works. But surgeons at NYU Langone Health hoped replacing the missing one would yield better cosmetic results for his new face, by supporting the transplanted eye socket and lid.

The NYU team announced Thursday that, so far, it’s doing just that. James is recovering well from the dual transplant last May and the donated eye looks remarkably healthy.

“It feels good. I still don’t have any movement in it yet. My eyelid, I can’t blink yet. But I’m getting sensation now,” James told the Associated Press as doctors examined his progress recently.

“You got to start somewhere, there’s got to be a first-person somewhere,” added James, 46, of Hot Springs, Arkansas. “Maybe you’ll learn something from it that will help the next person.”

Today, transplants of the cornea – the clear tissue in front of the eye – are common to treat certain types of vision loss. But transplanting the whole eye – the eyeball, its blood supply and the critical optic nerve that must connect it to the brain – is considered a moonshot in the quest to cure blindness.

Whatever happens next, James’s surgery offers scientists an unprecedented window into how the human eye tries to heal.

“We’re not claiming that we are going to restore sight,” said Dr Eduardo Rodriguez, NYU’s plastic surgery chief, who led the transplant. “But there’s no doubt in my mind we are one step closer.”

Some specialists had feared the eye would quickly shrivel like a raisin. Instead, when Rodriguez propped open James’s left eyelid last month, the donated hazel-colored eye was as plump and full of fluid as his own blue eye. Doctors see good blood flow and no sign of rejection.

Now researchers have begun analyzing scans of James’s brain that detected some puzzling signals from that all-important but injured optic nerve.

One scientist who has long studied how to make eye transplants a reality called the surgery exciting.

“It’s an amazing validation” of animal experiments that have kept transplanted eyes alive, said Dr Jeffrey Goldberg, chair of ophthalmology at California’s Stanford University.

The hurdle is how to regrow the optic nerve, although animal studies are making strides, Goldberg added. He praised the NYU team’s “audacity” in even aiming for optic nerve repair and hopes the transplant will spur more research.

“We’re really on the precipice of being able to do this,” Goldberg said.

James was working for a power line company in June 2021 when he was shocked by a live wire. He nearly died. Ultimately he lost his left arm, requiring a prosthetic. His damaged left eye was so painful it had to be removed. Multiple reconstructive surgeries couldn’t repair extensive facial injuries including his missing nose and lips.

James pushed through physical therapy until he was strong enough to escort his daughter Allie to a high school homecoming ceremony, wearing a face mask and eye patch. Still he required breathing and feeding tubes, and longed to smell, taste and eat solid food again.

“In his mind and his heart, it’s him – so I didn’t care that, you know, he didn’t have a nose. But I did care that it bothered him,” said his wife, Meagan James.

Face transplants remain rare and risky. James’s is only the 19th in the US.